ESMO Guideline sayd: "Follow-up of asymptomatic patients should include a blood cell count every 3–6 months, as well as a regular examinations of lymph nodes, liver and spleen. Special attention should be paid to the appearance of autoimmune cytopenias (autoimmune hemolytic anemia, autoimmune thrombocytopenia) that occur in 10%–15% of CLL patients and disease transformation". Eichorst recommended similarly in a 2011 article that: "CT scans not be used for CLL staging or follow-up outside of clinical trials, as supported by the current IWCLL guidelines."
B. Eichhorst et al, Chronic lymphocytic leukemia: ESMO Minimum Clinical Recommendations for diagnosis, treatment and follow-up, Ann Oncol (2009) 20 (suppl 4): iv102-iv104.
Eichhorst BF, Fischer K, Fink AM, et al. Limited clinical relevance of imaging techniques in the follow-up of patients with advanced chronic lymphocytic leukemia: results of a meta-analysis. Blood. 2010.
Barbara F. EichhorstLimited clinical relevance of imaging techniques in the follow-up of patients with advanced chronic lymphocytic leukemia: results of a meta-analysis, Blood, 10 February 2011, Vol. 117, No. 6, pp. 1817-1821.
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