Dasatinib, also known as BMS-354825, is a cancer drug produced by Bristol-Myers Squibb and sold under the trade name Sprycel. Dasatinib is a promising drug for melanoma and the clinicaltrials.gov websit lists 4 ongoing phase II trials, for example, Dasatinib in Treating Patients With Stage III Melanoma That Cannot Be Removed By Surgery or Stage IV Melanoma, NCT00436605. Melanomas from acral lentiginous, mucosal and chronic sun-damaged sites frequently harbor activating mutations and/or increased copy number in the KIT tyrosine kinase receptor gene, which are very rare in more common cutaneous melanomas. Multiple case reports and early observations from clinical trials suggested that targeting mutant KIT with small molecule KIT inhibitors such as imatinib (Gleevec, Novartis) and/or dasatinib (Sprycel, BristolMyersSquibb) is efficacious. Unfortunately, I was not able to find any published trial evidence to support the clincal use of dasatinib(Sprycel) for mealnoma at the current time.
nccn.org, melanoma
Wen-Jen Hwu, MD, PhD, HemOnc Today, Targeted therapy for metastatic melanoma: From bench to bedside June 25, 2010