Hypercoagulable states can be defined as a group of inherited or acquired conditions associated with a predisposition to venous thrombosis, arterial thrombosis, or both. Venous thromboembolic disease is the most common clinical manifestation resulting from hypercoagulable states. A number of inherited conditions can not be tested for; however, unfortunately there are no accepted guidelines as to what constitutes indications for such testing.The American College of Medical Genetics and the College of Maerican Pathologists state that this testing is appropriate to use widely because the polymorphisms that predispose to thromboses are fairly widespread; however, they have listed the situations in which thrombophilia testing should not be used. These include: for general screening, routine during pregnancy, routine screening prior to the use of oral contraceptives, prenatal or newborn screening , testing of asymptomatic children, routine testing in adults with an arterial thrombosis.
Colleen M. Johnson, MD Hypercoagulable States: A Review Vascular and Endovascular Surgery, Vol. 39, No. 2, 123-133 (2005)
Seligsohn U, Lubetsky A. Genetic susceptibility to venous thrombosis. N Engl J Med. 2001;344:1222-1231.
De Stefano V, Casorelli I, Rossi E, et al: Interaction between hyperhomocysteinemia and inherited thrombophilic factors in venous thromboembolism. Semin Thromb Hemost 2000;26:305-311
A.Auerbach, G.Sanders, J.HambletonCost-effectiveness of testing for hypercoagulability and effects on treatment strategies in patients with deep vein thrombosis
The American Journal of Medicine, Volume 116, Issue 12, Pages 816-828, 2004
http://www.genomedical.org/documents/TestingRecommendations.pdf
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